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Integrin beta-2 (CD18) is a protein that in humans is encoded by the ''ITGB2'' gene. It is the beta subunit of four different structures: * LFA-1 (paired with CD11a) * Macrophage-1 antigen (paired with CD11b) * Integrin alphaXbeta2 (paired with CD11c) * Integrin alphaDbeta2 (paired with CD11d) == Function == The ITGB2 protein product is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3689 )〕 In humans lack of CD18 causes Leukocyte Adhesion Deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「CD18」の詳細全文を読む スポンサード リンク
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