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CD207 : ウィキペディア英語版
Langerin

CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the ''CD207'' gene.〔 Langerin is a type II transmembrane, C-type lectin receptor on Langerhans cells.〔
==Function==
The protein encoded by this gene is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Additionally it is known by the name ''C-type lectin domain family 4 member K (CD antigen ''CD207'')''. It is also expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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