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CDX2 : ウィキペディア英語版
CDX2

CDX-2 is a homeobox gene that encodes the CDX-2 protein - a transcription factor expressed in the nuclei of intestinal epithelial cells.
== Function ==
Cdx2 is the gene that directs early embryogenesis in mice. It is required to form the placenta.
Ectopic expression of CDX2 was reported in more than 85% of the human patients with acute myeloid leukemia (AML). Ectopic expression of Cdx2 in murine bone marrow induced AML in mice and upregulate Hox genes in bone marrow progenitors.〔 CDX2 is also implicated in the pathogenesis of Barrett's esophagus where it has been shown that components from gastroesofageal reflux such as bile acids are able to induce the expression of an intestinal differentiation program through up-regulation of NF-κB and CDX2.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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