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The CHADS2 score is a clinical prediction rule for estimating the risk of stroke in patients with non-rheumatic atrial fibrillation (AF), a common and serious heart arrhythmia associated with thromboembolic stroke. It is used to determine whether or not treatment is required with anticoagulation therapy or antiplatelet therapy, since AF can cause stasis of blood in the upper heart chambers, leading to the formation of a mural thrombus that can dislodge into the blood flow, reach the brain, cut off supply to the brain, and cause a stroke. A high CHADS2 score corresponds to a greater risk of stroke, while a low CHADS2 score corresponds to a lower risk of stroke. The CHADS2 score is simple and has been validated by many studies. The CHADS2 score does not include some common stroke risk factors and its various pros/cons have been carefully discussed.〔Karthikeyan G, Eikelboom JW. The CHADS2 score for stroke risk stratification in atrial fibrillation--friend or foe? Thromb Haemost. 2010 Jul 5;104(1):45-8.〕 The CHADS2 scoring table is shown below:〔(【引用サイトリンク】title=Risk of Stroke with AF )〕 adding together the points that correspond to the conditions that are present results in the CHADS2 score, that is used to estimate stroke risk. ==CHA2DS2-VASc== To complement the CHADS2 score, by the inclusion of additional 'stroke risk modifier' risk factors, the CHA2DS2-VASc-score has been proposed.〔Lip GY, Nieuwlaat R, Pisters R, Lane DA, Crijns HJ. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation. Chest. 2010 Feb;137(2):263-72.〕 In clinical use, the CHADS2 score has been superseded by the CHA2DS2-VASc score that gives a better stratification of low-risk patients. The CHADS2 score has been outperformed by the CHA2DS2-VASc in multiple patient groups including patients with AF who are receiving outpatient elective electrical cardioversion. Thus, the CHA2DS2-VASc〔http://www.mdcalc.com/cha2ds2-vasc-score-for-atrial-fibrillation-stroke-risk/〕〔http://www.saheart.com.au/for-doctors/clinical-tools/cha2ds2-vasc-score.html〕〔http://www.gpnotebook.co.uk/simplepage.cfm?ID=x20110126111352933383〕 score is a refinement of CHADS2〔http://heart.bmj.com/content/early/2011/11/10/heartjnl-2011-300901.abstract〕〔http://journal.publications.chestnet.org/article.aspx?articleid=1086288〕 score and extends the latter by including additional common stroke risk factors, that is, age 65-74, female gender and vascular disease. In the CHA2DS2-VASc score, 'age 75 and above' also has extra weight, with 2 points. The maximum CHADS2 score is 6, whilst the maximum CHA2DS2-VASc score is 9 (for age, either the patient is ≥75 years and gets two points, is between 65-74 and gets one point, or is under 65 and does not get points). 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「CHA2DS2–VASc score」の詳細全文を読む スポンサード リンク
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