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CHOP : ウィキペディア英語版
CHOP

CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma. CHOP consists of:
* (C)yclophosphamide, an alkylating agent which damages DNA by binding to it and causing the formation of cross-links
* (H)ydroxydaunorubicin (also called doxorubicin or Adriamycin), an intercalating agent which damages DNA by inserting itself between DNA bases
* (O)ncovin (vincristine), which prevents cells from duplicating by binding to the protein tubulin
* (P)rednisone or (P)rednisolone, which are corticosteroids.
== Dosing regimen ==

R-Maxi-CHOP is used in mantle cell lymphoma and is given in 21-day intervals, alternating with R-HDAC (rituximab + high-dose cytarabine).〔(Nordic Protocol (Maxi-CHOP and High Dose Cytarabine) for Mantle Cell Lymphoma (MCL) )〕
In most other non-Hodgkin lymphomas (excluding some aggressive forms), standard-dose ()-CHOP is generally used as first-line therapy.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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