翻訳と辞書 Words near each other ・ CI ・ Ci (poetry) ・ CI Capital Partners ・ CI chondrite ・ Ci County ・ CI Financial ・ CI Games ・ Ci protein ・ CI Records ・ CI Resources ・ Ci rimani male/Chimica Brother ・ CI Rosalía de Castro ・ Ci sarà ・ Ci vediamo a casa ・ CI&T ・ CI-1017 ・ CI-966 ・ CI-988 ・ Ci-devant ・ CI1 fossils ・ CIA (disambiguation) ・ CIA activities in Afghanistan ・ CIA activities in Africa ・ CIA activities in Angola ・ CIA activities in Asia ・ CIA activities in Brazil ・ CIA activities in Cambodia ・ CIA activities in Canada ・ CIA activities in Chad ・ CIA activities in China Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク CI-1017 ： ウィキペディア英語版 CI-1017 CI-1017 is a muscarinic acetylcholine receptor agonist which is selective for and is approximately equipotent at the M1 and M4 receptors, with 20-30-fold lower affinity for the M2, M3, and M5 subtypes It is the (''R'')-enantiomer of the racemic compound PD-142,505.〔 In animals CI-1017 improves learning and memory and increases the electrical activity of the hippocampus through activation of the M1 receptor, while minimally producing parasympathetic side effects and only at very high doses. It also inhibits production of amyloidogenic A beta peptide and increases secretion of soluble amyloid precursor protein via stimulation of the M1 receptor as well.〔 Based on these data, it was hypothesized that CI-1017 could not only treat the symptoms of Alzheimer's disease, but could also potentially slow its progression.〔 It was tested in clinical trials for this purpose in the early 2000s but was apparently abandoned for unknown reasons.〔 == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「CI-1017」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.