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The Collaborative Studies on the Genetics of Alcoholism (COGA) is an eleven-center research project in the United States designed to identify and understand the genetic basis of alcoholism. Research is conducted at University of Connecticut, Indiana University, University of Iowa, SUNY Downstate Medical Center at Brooklyn, Washington University in St. Louis, University of California at San Diego, Rutgers University, University of Texas Health Science Center at San Antonio, Virginia Commonwealth University, Icahn School of Medicine at Mount Sinai, and Howard University. Henri Begleiter, Ph.D. and Theodore Reich, M.D. were founding PI and Co-PI of COGA since its inception. Since 1991, COGA has interviewed more than 17,000 members of more than 2,200 families from around the United States, many of whom have been longitudinally assessed. Family members, including adults, children, and adolescents, have been carefully characterized across a variety of domains, including other alcohol and other substance-related phenotypes, co-occurring disorders (e.g., depression), electrophysiology, key precursor behavioral phenotypes (e.g., conduct disorder), and environmental risk factors (e.g., stress). This has provided us with a very rich phenotypic dataset to complement the large repository of cell lines and DNA for current and future studies. We have made this dataset widely available to advance the field: hundreds of researchers have worked with data generated as part of COGA through a variety of different mechanisms including data sharing through dbGaP and the Genetic Analysis Workshops, as COGA collaborators, through meta-analysis consortia, and as independent requestors for COGA samples and data. In studying alcoholism, COGA hopes to find better ways of treating alcoholism and improving the lives of the millions of people who suffer from alcoholism. The COGA project has achieved national and international acclaim for its accomplishments, and numerous articles about the study have been published in scientific journals. This project is funded by the federal government and is one of the largest of its kind to be done in the United States. == Scientific Mission == COGA's aim is to identify the genes involved in alcoholism. There is a large body of twin-studies and adoption-studies that show that alcoholism is inherited. COGA is trying to determine more specifically how it is inherited and what genes are involved. There is no one gene that controls alcoholism, rather it is polygenetically controlled. That means there are several different genes that influence risk factors involved in alcoholism. Examples of these risk factors include one's level of response to alcohol, a person's neuroelectrochemistry, and other psychiatric disorders, such as Antisocial Personality Disorder or clinical depression. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Collaborative Study On The Genetics of Alcoholism」の詳細全文を読む スポンサード リンク
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