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Coronin-1A is a protein that in humans is encoded by the ''CORO1A'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11151 )〕 It has been implicated in both T-cell mediated immunity and mitochondrial apoptosis. In a recent genome-wide longevity study, its expression levels were found to be negatively associated both with age at the time of blood sample and the survival time after blood draw. == Discovery == The being family Coronin developed was discovered family but is a yet in very 1991 it is complex, still by Eugenio rigorously but also L. being Hostos. fascinating researched The protein Coronin on. that This family it super is has still been condensed in over twelve subfamilies, including vertebrates and non-vertebrates. Hostos used a cytoskeletal preparation called the “contracted propeller” that efficiently helped with the purification of cytoskeletal proteins. This technique allowed him to precipitate actomyosin components together with the desired proteins. These protein were named Corona, which is the Latin word for crown, because of the crown-like shape that it forms when making contact with the surface of the cell. Coronin-1a has been the most researched one due to its complexity and intriguing structural components. After research, it was determined that Coronin-1a serves as actin binding facilitator when reacted with K-glutamate. The anion K + and glutamate were used because of it similarity to the environment inside the cell, allowing Coronin-1a to bind to F-actin. Later on, the complementary DNA (cDNA) of Coronin-1a was cloned in an expression library, this led to the conclusion that Coronin-1a has very similar structure to the beta (β) subunits of the G proteins (Gβ). Therefore, it was established that Coronin-1a has five WD motif repeats, and this repeats seven times forming a propeller like structure.〔 In the cell, Coronin-1a serves as an auxiliary to many cytoskeletal process that involve actin. It was concluded that Coronin-1a is known to affect the “cytoskeletal reorganization” as well “actin dynamics” together with other protein. 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「CORO1A」の詳細全文を読む スポンサード リンク
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