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Prostaglandin-endoperoxide synthase 2
Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (The HUGO official symbol is PTGS2; HGNC ID, HGNC:9605), also known as cyclooxygenase-2 or COX-2, is an enzyme that in humans is encoded by the ''PTGS2'' gene. Because the "COX" term is used for the stem symbol for "cytochrome c oxidase" family of genes and gene products including proteins, the "PTGS" symbol is used for the prostaglandin-endoperoxide synthase (cyclooxygenase) family of genes and proteins. It is involved in the conversion of arachidonic acid to prostaglandin H2, an important precursor of prostacyclin and thromboxane A2, among others. == History ==
PTGS2 (COX-2) was discovered in 1991 by the Daniel Simmons laboratory at Brigham Young University.
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