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CP-55,940 : ウィキペディア英語版
CP 55,940

CP 55,940 is a cannabinoid which mimics the effects of naturally occurring THC (one of the psychoactive compounds found in cannabis). CP 55,940 was created by Pfizer in 1974 but was never marketed. It is currently used to study the endocannabinoid system. Some effects that have been noted are a greatly decreased rates of lever pressing in exposed mice, and a greater reaction to opiates in exposed mice.
A study found that CP 55,940 can upregulate 5-HT2A receptors in mice.
CP 55,940 is 45 times more potent than Δ9-THC, and fully antagonized by rimonabant (SR141716A).
CP 55,940 is considered a full agonist at both CB1 and CB2 receptors and has Ki values of 0.58nM and 0.68nM respectively, but is an antagonist at GPR55, the putative "CB3" receptor.
CP 55,940 showed protective effects on rat brain mitochondria upon paraquat exposure.
It also showed neuroprotective effects by reducing intracellular calcium release and reducing hippocampal cell death in cultured neurons subjected to high levels of NMDA.
CP 55,940 induced cell death in NG 108-15 Mouse neuroblastoma x Rat glioma hybrid brain cancer (genetically engineered mouse x rat brain cancer) cells.〔(【引用サイトリンク】 General Cell Collection: NG108-15 )
==See also==

* CP 47,497

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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