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CP-93129
CP-93129 is a drug which acts as a potent and selective serotonin 5-HT1B receptor agonist, with approximately 150x and 200x selectivity over the closely related 5-HT1D and 5-HT1A receptors.〔Macor JE, Burkhart CA, Heym JH, Ives JL, Lebel LA, Newman ME, Nielsen JA, Ryan K, Schulz DW, Torgersen LK, et al. 3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo()pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole. ''Journal of Medicinal Chemistry''. 1990 Aug;33(8):2087-93. PMID 2374139〕 It is used in the study of 5-HT1B receptors in the brain, particularly their role in modulating the release of other neurotransmitters.〔De Groote L, Olivier B, Westenberg HG. Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice. ''European Journal of Pharmacology''. 2003 Aug 22;476(1-2):71-7. PMID 12969751〕〔Przegaliński E, Papla I, Siwanowicz J, Filip M. Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats. ''European Neuropsychopharmacology''. 2004 May;14(3):217-25. PMID 15056481〕〔Bramley JR, Sollars PJ, Pickard GE, Dudek FE. 5-HT1B receptor-mediated presynaptic inhibition of GABA release in the suprachiasmatic nucleus. ''Journal of Neurophysiology''. 2005 Jun;93(6):3157-64. PMID 15716370〕〔Saitow F, Murano M, Suzuki H. Modulatory effects of serotonin on GABAergic synaptic transmission and membrane properties in the deep cerebellar nuclei. ''Journal of Neurophysiology''. 2009 Mar;101(3):1361-74. PMID 19144744〕
==References==
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