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CP-94253
CP-94253 is a drug which acts as a potent and selective serotonin 5-HT1B receptor agonist, with approximately 25x and 40x selectivity over the closely related 5-HT1D and 5-HT1A receptors.〔Koe KB, Nielsen JA, Macor JE, Heym J. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. ''Drug Development Research''. 1992;26(3):241-250. 〕 It has a range of behavioural effects in animal studies, including promoting wakefulness by increasing dopamine release in the brain,〔Monti JM, Monti D, Jantos H, Ponzoni A. Effects of selective activation of the 5-HT1B receptor with CP-94,253 on sleep and wakefulness in the rat. ''Neuropharmacology''. 1995 Dec;34(12):1647-51. PMID 8788962〕〔Iyer RN, Bradberry CW. Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization. ''Journal of Pharmacology and Experimental Therapeutics''. 1996 Apr;277(1):40-7. PMID 8613947〕 reducing food intake and promoting satiety,〔Halford JC, Blundell JE. The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence. ''Physiology and Behaviour''. 1996 Sep;60(3):933-9. PMID 8873272〕〔Lee MD, Simansky KJ. CP-94,253: a selective serotonin1B (5-HT1B) agonist that promotes satiety. ''Psychopharmacology (Berlin)''. 1997 Jun;131(3):264-70. PMID 9203237〕〔Lee MD, Kennett GA, Dourish CT, Clifton PG. 5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253. ''Psychopharmacology (Berlin)''. 2002 Oct;164(1):49-60. PMID 12373419〕 enhancing the reinforcing effects of cocaine,〔Parsons LH, Weiss F, Koob GF. Serotonin1B receptor stimulation enhances cocaine reinforcement. ''Journal of Neuroscience''. 1998 Dec 1;18(23):10078-89. PMID 9822762〕〔Przegalinski E, Filip M, Papla I, Siwanowicz J. Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats. ''Behavioural Pharmacology''. 2001 Apr;12(2):109-16. PMID 11396515〕 and possible antidepressant effects.〔Tatarczyńska E, Antkiewicz-Michaluk L, Kłodzińska A, Stachowicz K, Chojnacka-Wójcik E. Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action. ''European Journal of Pharmacology''. 2005 May 23;516(1):46-50. PMID 15913599〕
==References==
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