|
CREB (cAMP response element-binding protein)〔Bourtchuladze et al. "Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein." ''Cell'' Genes whose transcription is regulated by CREB include: ''c-fos'', BDNF, tyrosine hydroxylase, numerous neuropeptides (such as somatostatin, enkephalin, VGF, corticotropin-releasing hormone),〔 and genes involved in the mammalian circadian clock (PER1, PER2). CREB is closely related in structure and function to CREM (cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are expressed in many animals, including humans. CREB has a well-documented role in neuronal plasticity and long-term memory formation in the brain and has been shown to be integral in the formation of spatial memory.〔Silva et al. ("CREB and Memory" ), ''Annual Review of Neuroscience'', 21:127-148〕 CREB downregulation is implicated in the pathology of Alzheimer's disease and increasing the expression of CREB is being considered as a possible therapeutic target for Alzheimers disease.〔Downregulation of CREB expression in Alzheimer’s brain and in Ab-treated rat hippocampal neurons〕 CREB also has a role in photoentrainment in mammals. ==Subtypes== The following genes encode CREB or CREB-like proteins: * CREB1 () * CREB2 renamed ATF4 () * CREB3 () * CREB5 () * CREB3L1 () * CREB3L2 () * CREB3L3 () * CREB3L4 () 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「CREB」の詳細全文を読む スポンサード リンク
|