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Prostaglandin DP2 receptor
Prostaglandin D2 receptor 2 (DP2) is a human protein encoded by the PTGDR2 gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11251 )〕 DP2 has also been designated as CD294 (cluster of differentiation 294).
DP2 has recently been found when activated by elevated level of prostaglandin D2 (PGD2), it could inhibit hair growth. This suggests the DP2 pathway as a potential target for bald treatment.〔(Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia )〕 A particularly promising compound for blocking the DP2 pathway is a compound known as TM30089, which exhibits a "functional insurmountability" of PGD2 expression.〔http://molpharm.aspetjournals.org/content/69/4/1441〕 ==Ligands==
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Prostaglandin DP2 receptor」の詳細全文を読む
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