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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク CXCL3 ： ウィキペディア英語版 CXCL3 Chemokine (C-X-C motif) ligand 3 (CXCL3) is a small cytokine belonging to the CXC chemokine family that is also known as ''GRO3 oncogene'' (GRO3), ''GRO protein gamma'' (GROg) and ''macrophage inflammatory protein-2-beta'' (MIP2b). CXCL3 controls migration and adhesion of monocytes and mediates its effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2. More recently, it has been shown that Cxcl3 regulates cell autonomously the migration of the precursors of cerebellar granule neurons toward the internal layers of cerebellum, during the morphogenesis of cerebellum. Moreover, if the expression of Cxcl3 is reduced in cerebellar granule neuron precursors, this highly enhances the frequency of the medulloblastoma, the tumor of cerebellum. In fact, the reduced expression of Cxcl3 forces the cerebellar granule neuron precursors to remain at the surface of the cerebellum, where they highly proliferate under the stimulus of Sonic hedgehog, becoming target of transforming insults. Remarkably, the treatment with CXCL3 reduces the area of medulloblastoma lesions in a mouse model of medulloblastoma. Thus, CXCL3 is a potential target for medulloblastoma therapy. Cxcl3 is directly regulated transcriptionally by BTG2 〔 The gene for CXCL3 is located on chromosome 4 in a cluster of other CXC chemokines. ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「CXCL3」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.