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Cabotegravir : ウィキペディア英語版 | Cabotegravir
|Section2= |Section3= }} Cabotegravir (USAN〔(【引用サイトリンク】url=http://www.ama-assn.org/resources/doc/usan/x-pub/cabotegravir.pdf )〕 and INN〔(【引用サイトリンク】url=http://www.who.int/medicines/publications/druginformation/PL_111.pdf )〕) (also known as S/GSK1265744 or GSK744) is an investigational new drug under development for the treatment of HIV infection. It is an integrase inhibitor, with a carbamoyl pyridone structure similar to dolutegravir. In investigational studies, the agent has been packaged into nanoparticles (GSK744LAP) conferring an exceptionally long half-life of 21–50 days following a single dose. In theory, this would make possible suppression of HIV with dosing as infrequently as once every three months.〔(PrEP GSK744 Integrase Administered Monthly Perhaps Quarterly Prevents HIV-Infection in Monkeys ). 20th Conference on Retroviruses and Opportunistic Infections. Atlanta, GA March 3–6, 2013.〕 ==References==
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