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Calcification : ウィキペディア英語版 | Calcification
Calcification is the accumulation of calcium salts in a body tissue. It normally occurs in the formation of bone, but calcium can be deposited abnormally in soft tissue,〔Miller, J. D. Cardiovascular calcification: Orbicular origins. ''Nature Materials'' 12, 476-478 (2013).〕 causing it to harden. Calcifications may be classified on whether there is mineral balance or not, and the location of the calcification.〔(Calcification ) The American Heritage Science Dictionary. Retrieved 2013-03-23.〕 ==Causes of soft tissue calcification==
Calcification of soft tissue (arteries, cartilage, heart valves,〔〔 etc.) can be caused by vitamin K2 deficiency or by poor calcium absorption due to a high calcium/vitamin D ratio. This can occur with or without a mineral imbalance. Intake of excessive Vitamin D can cause Vitamin D poisoning and excessive intake of calcium from the intestine, when accompanied by a deficiency of vitamin K (perhaps induced by an anticoagulant) can result in calcification of arteries and other soft tissue.〔Paul Price, ''et al''., ( "Warfarin-Induced Artery Calcification Is Accelerated by Growth and Vitamin D" ), ''Arteriosclerosis, Thrombosis, and Vascular Biology'', 2000, Vol. 20, pp. 317-327.〕 Such metastatic soft tissue calcification is mainly in tissues containing "calcium catchers" such as elastic fibres or sour mucopolysaccharides. These tissues especially include the lungs (pumice lung) and the aorta.〔McGavin, Zachary. ''Pathologic basis of veterinary disease'', fourth edition; Elsevier 2007.〕
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