翻訳と辞書 Words near each other ・ Calcium reactor ・ Calcium release activated channel ・ Calcium signaling ・ Calcium silicate ・ Calcium silicate hydrate ・ Calcium silicide ・ Calcium sorbate ・ Calcimicrobe ・ Calcimimetic ・ Calcinaia ・ Calcinara ・ Calcinate ・ Calcination ・ Calcinato ・ Calcinea ・ Calcineurin ・ Calcineurin-like phosphoesterase ・ Calcinosis ・ Calcinosis cutis ・ Calcinus ・ Calcinus elegans ・ Calcinus tubularis ・ Calcinus verrillii ・ Calcio ・ Calcio 2000 ・ Calcio Catania ・ Calcio Como ・ Calcio Fiorentino ・ Calcio Lecco 1912 ・ Calcio Montebelluna Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Calcineurin ： ウィキペディア英語版 Calcineurin Calcineurin (CN) is a calcium and calmodulin dependent serine/threonine protein phosphatase (also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase). It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates nuclear factor of activated T cell, cytoplasmic (NFATc), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which includes cyclosporine, pimecrolimus and tacrolimus. == Structure == Calcineurin is a heterodimer of a 61-kD calmodulin-binding catalytic subunit, calcineurin A and a 19-kD Ca2+-binding regulatory subunit, calcineurin B. There are three isozymes of the catalytic subunit, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two isoforms of the regulatory, also encoded by separate genes (PPP3R1, PPP3R2). 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Calcineurin」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.