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Words near each other
・ Calpionella
・ Calpionellidae
・ Calpionellites darderi
・ Calpis
・ Calpocalyx
・ Calpocalyx atlanticus
・ Calpocalyx brevifolius
・ Calpocalyx cauliflorus
・ Calpocalyx heitzii
・ Calpocalyx klainei
・ Calpocalyx letestui
・ Calpocalyx ngouiensis
・ Calpodes
・ Calpodes ethlius
・ Calponia harrisonfordi
Calponin
・ Calponin 1, basic, smooth muscle
・ Calponin 2
・ Calponin 3, acidic
・ Calponin family repeat
・ Calponin homology domain
・ Calpoparia
・ Calprotectin
・ CALPUFF
・ Calpulalpan (municipality)
・ Calpulli
・ Calpulli Airport
・ Calpurnia
・ Calpurnia (gens)
・ Calpurnia (genus)


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Calponin : ウィキペディア英語版
Calponin

Calponin is a calcium binding protein. Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. Phosphorylation of calponin by a protein kinase, which is dependent upon calcium binding to calmodulin, releases the calponin's inhibition of the smooth muscle ATPase.
== Structure and function ==
Calponin is mainly made up of α-helices with hydrogen bond turns. It is a binding protein and is made up of three domains. These domains in order of appearance are Calponin Homology (CH), regulatory domain (RD), and Click-23, domain that contains the calponin repeats. At the CH domain calponin binds to α-actin and filamin and binds to actin within the RD domain. Calmodulin, when activated by calcium may bind weakly to the CH domain and inhibit calponin binding with α-actin. Calponin is responsible for binding many actin binding proteins, phospholipids, and regulates the actin/myosin interaction. Calponin is also thought to negatively affect the bone making process due to being expressed in high amounts in osteoblasts.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Calponin」の詳細全文を読む



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