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Calretinin also known as 29 kDa calbindin is a calcium-binding protein involved in calcium signaling.〔 〕 In humans, the calretinin protein is encoded by the ''CALB2'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=794 )〕 == Function == This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering.〔 Calretinin is abundantly expressed in neurons including retina (which gave it the name)〔 and cortical interneurons.〔 〕 Expression was found in different neurons than that of the similar vitamin D-dependent calcium-binding protein, calbindin-28kDa.〔 Calretinin has an important role as a modulator of neuronal excitability including the induction of long-term potentiation.〔 〕 Loss of expression of calretinin in hippocampal interneurons has been suggested to be relevant in temporal lobe epilepsy.〔 〕 It is expressed in a number of other locations including hair follicles. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Calretinin」の詳細全文を読む スポンサード リンク
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