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Candoxatril : ウィキペディア英語版
Candoxatril

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Candoxatril is the orally active prodrug of candoxatrilat (UK-73967) human neutral endopeptidase (Neprilysin) as the neutral endopeptidase 24.11 complexed (RB-101) with phosphoramidon degrades and inactivates a number of bioactive peptides. Two multiply connected folding domains〔 of the neutral endopeptidase locus〔 splicing of exons 1, 2a, or 2b to the common exon 3 composed of 24 exons of the human CALLA/NEP gene〔 containing the active site, it is known as peptidase family M13 (neprilysin family, clan MA(E)) the gluzincins a faint but significant structural relationship of the metzincins〔(【引用サイトリンク】 url = http://www.expasy.org/prosite/PDOC00129 )〕〔(【引用サイトリンク】 url = http://www.ebi.ac.uk/intenz/query?cmd=SearchEC&ec=3.4.15.4 )〕 to the thermolysin-like enzymes,〔 Zincin is the simplest descriptor of biological space. The structure reveals two multiply connected folding domains which embrace a large central cavity containing the active site of the 5-indanyl ester prodrug candoxatril and differs from phosphoramidon (leucyl)-L-tryptophan ) in several respects the structure of human neutral endopeptidase complexed with phosphoramidon is lost due to desolvation〔 of the enzyme and ligand on formation of the complex Candoxatril.
== See also ==

* Ecadotril

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Candoxatril」の詳細全文を読む



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