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Cardiomegaly
Cardiomegaly is a medical condition in which the heart is enlarged. It is more commonly referred to as an enlarged heart. The causes of cardiomegaly may vary. Many times this condition results from high blood pressure hypertension or coronary artery disease. An enlarged heart may not pump blood effectively, resulting in congestive heart failure. Cardiomegaly may improve over time, but many people with an enlarged heart need lifelong treatment with medications.〔(【引用サイトリンク】title=What Is an Enlarged Heart (Cardiomegaly)? )〕 Having an immediate family member who has or had cardiomegaly may make you more susceptible to getting this condition.〔http://www.mayoclinic.org/diseases-conditions/enlarged-heart/basics/risk-factors/con-20034346〕 Cardiomegaly is not a disease but rather a condition that can result from a host of other diseases such as obesity or coronary artery disease. Recent studies suggest that cardiomegaly is associated with a higher risk of sudden cardiac death (SCD).〔(【引用サイトリンク】title=Cardiomegaly is a common arrhythmogenic substrate in adult sudden cardiac deaths, and is associated with obesity. )〕
==Mechanism==
Cardiomegaly is a condition effecting the cardiovascular system, specifically the heart. This condition is strongly associated with congestive heart failure.〔 Within the heart, the working fibers of the myocardial tissue increase in size. As the heart works harder the actin and myosin filaments experience less overlap which increases the size of the myocardial fibers. If there is less overlap of the protein filaments actin and myosin within the sarcomeres of muscle fibers, they will not be able to effectively pull on one another. If the heart tissue (walls of left and right ventricle) gets too big and stretches too far, then those filaments cannot effectively pull on one another to shorten the muscle fibers, thus impacting the heart's sliding filament mechanism. If fibers cannot shorten properly, and the heart cannot contract properly, then blood cannot be effectively pumped to the lungs to be re-oxygenated and to the body to deliver oxygen to the working tissues of the body.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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