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Cariprazine : ウィキペディア英語版
Cariprazine

Cariprazine (trade name Vraylar, previously known as RGH-188) is an antipsychotic drug developed by Gedeon Richter. It acts as a D2 and D3 receptor partial agonist, with high selectivity towards the D3 receptor. Positive Phase III study results were published for schizophrenia and mania in early 2012, and for bipolar disorder I depression from a Phase II trial in 2015. 〔http://ajp.psychiatryonline.org/doi/abs/10.1176/appi.ajp.2015.15020164〕 Action on the dopaminergic systems makes it also potentially useful as an add-on therapy in major depressive disorder 〔(Clinical trial : Safety and Efficacy of Caripazine As Adjunctive Therapy In Major Depressive Disorder )〕
Rights are currently owned by Gedeon Richter and Actavis. The drug received FDA approval on September 17, 2015.〔(【引用サイトリンク】url=http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm463103.htm )
==Medical uses==
Cariprazine is approved for schizophrenia and bipolar disorder. It has also been investigated as a potential adjunct in treatment-resistant major depressive disorder.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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