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Caspofungin : ウィキペディア英語版
Caspofungin

Caspofungin (INN〔(European Medicines Agency's list of authorised medicines for human use (C) )〕) (brand name Cancidas worldwide) is a lipopeptide antifungal drug from Merck & Co., Inc. discovered by James Balkovec, Regina Black and Frances A. Bouffard.〔(【引用サイトリンク】website=https://www.google.com/patents/US5378804?dq=5378804&hl=en&sa=X&ei=pHIJVZntI4uWNpStg6gK&ved=0CB0Q6AEwAA )〕 It is a member of a new class of antifungals termed the echinocandins. It works by inhibiting the enzyme (1→3)-β-D-glucan synthase and thereby disturbing the integrity of the fungal cell wall. Caspofungin was the first inhibitor of fungal (1→3)-β-D-glucan synthesis to be approved by the United States Food and Drug Administration.
Caspofungin is administered intravenously.
==Spectrum of fungal susceptibility and resistance==
Caspofungin has been effective in treating fungal infections caused by ''Aspergillus'' and ''Candida'' species. The following represents MIC susceptibility for a few medically significant organisms.〔http://www.toku-e.com/Assets/MIC/Caspofungin%20acetate.pdf〕
* ''Candida albicans'' 0.015 - 16 μg/ml
* ''Candida krusei'' 0.03 - 8 μg/ml
* ''Cryptococcus neoformans'' 16 μg/ml

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Caspofungin」の詳細全文を読む



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