翻訳と辞書
Words near each other
・ Cavum veli interpositi
・ Cavum Vergae
・ Cavungi
・ Cavus
・ Cavuto on Business
・ Cavé
・ CAW
・ Caw (hill)
・ Caw Fell
・ CAW Local 111
・ CAW Local 1285
・ CAW Local 1973
・ CAW Local 200
・ Cavicocorp
・ Cavicularia
Cavicularin
・ Cavidabad
・ Caviezel
・ Cavigal Nice Basket
・ Caviglia
・ Cavigliano
・ Cavignac
・ Cavigny
・ Cavihemiptilocera
・ Caviidae
・ Caviinae
・ Cavil
・ Cavilaelaps
・ Cavill
・ Cavill Avenue


Dictionary Lists
翻訳と辞書 辞書検索 [ 開発暫定版 ]
スポンサード リンク

Cavicularin : ウィキペディア英語版
Cavicularin

|Section2=
|Section3=
}}
Cavicularin is a natural phenolic secondary metabolite isolated from the liverwort ''Cavicularia densa''. This macrocycle is unusual because it was the first compound isolated from nature displaying optical activity solely due to the presence of planar chirality and axial chirality. The specific rotation for (+)-cavicularin is +168.2°. It is also a very strained molecule. The ''para''-substituted phenol ring is bent about 15° out of planarity, adopting a somewhat boat-like geometry. This type of angle strain in aromatic compounds is normally reserved for synthetic cyclophanes.
:
The liverwort was obtained from Mt. Ishizuchi in the district of Shikoku. The material was dried for one day, ground to a powder and 5 grams were refluxed in methanol for 4 months to yield 2.5 mg (0.049%) of cavicularin after column chromatography and preparative TLC.
:
== Total synthesis ==
In 2005 and again in 2011, the compound was prepared by total synthesis together with the unstrained compound riccardin C. The strategy used was a radical reaction. In 2013 several procedures have been reported, one based on transannulation, one based on a Diels-Alder reaction and one (racemic) based on a coupling reaction.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Cavicularin」の詳細全文を読む



スポンサード リンク
翻訳と辞書 : 翻訳のためのインターネットリソース

Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.