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Cdx
The Cdx gene family, also called caudal genes, are a group of genes found in many animal genomes. Cdx genes contain a homeobox DNA sequence and code for proteins that act as transcription factors. The gene after which the gene family is named (the founding member) is the ''caudal'' or ''cad'' gene of the fruitfly ''Drosophila melanogaster''.〔Mlodzik, M., Fjose, A. and Gehring, W.J. (1985). Isolation of caudal, a Drosophila homeobox-containing gene with maternal expression, whose transcription form a concentration gradient at the pre-blastoderm stage. EMBO J. 4: 2961-296〕〔(【引用サイトリンク】url=http://www.sdbonline.org/fly/gene/caudal.htm )〕 The human genome has three Cdx genes, called ''CDX1'', ''CDX2'' and ''CDX4''. The zebrafish has no ''cdx2'' gene, but two copies of ''cdx1'' and one copy of ''cdx4''.〔Mulley, J.F., Chiu, C.-H. and Holland, P.W.H. (2006) Break-up of a homeobox gene cluster after genome duplication in teleosts. PNAS 103: 10369-10372.〕 The Cdx gene in the nematode ''Caenorhabditis elegans'' is called ''pal-1''.〔Baugh, L. R., et al. (2005). The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo. Development 132(8): 1843-54〕 In many animals, the Cdx gene is part of a ParaHox gene cluster.〔Brooke et al 1998 Nature 392: 920-922. PMID 9582071〕 ==References== 〔
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