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Centralspindlin is a motor complex implicated in cell division. It contributes to virtually every step in Cytokinesis,〔Glotzer, Michael. ("Cytokinesis: Centralspindlin Moonlights as a Membrane Anchor" ), ''Current Biology'', 18 February 2013〕 It is highly conserved in animal cells as a component of the spindle midzone and midbody.〔Glotzer, Michael (" The 3Ms of central spindle assembly: microtubules, motors and MAPs" ), ''Nature (Journal)'', January 2009〕 Centralspindlin is required for the assembly of the mitotic spindle〔Nature Publishing Group. ("Research Highlights" ), ''Cell Migration Consortium'', 2009. Retrieved on 01 March 2014.〕 as well as for microtubule bundling and anchoring of midbody microtubules to the plasma membrane.〔〔 This complex is also implicated in tethering the spindle apparatus to the plasma membrane during cytokinesis〔Lekomtsev et al. ("Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis" ), ''Nature (Journal)'', 13 December 2012〕 This interaction permits cleavage furrow ingression. In addition, centralspindlin's interaction with the ESCRT III allows for abscission to occur.〔 == Structure == Centralspindlin is a heteroteramer consisting of two different subunit proteins:〔 # A KIF23 dimer (Kinesin 6 motor protein, also known as MKLP1 in ''C. elegans'') ::Consists of a motor domain linked a parallel coiled coil and a globular region by a linker # A RACGAP1 dimer (Also known as MgcRacGAP, KRT4 or CYK4 in ''C. elegans'') ::Contains a coiled-coil and an important RhoGAP domain Both KIF23 and RacGAP1 dimerize via their parallel coiled coil domain.〔〔Pavicic-Kaltenbrunner et al. ("Cooperative assembly of CYK-4/MgcRacGAP and ZEN-4/MKLP1 to form the centralspindlin complex" ), ''Molecular Biology of the Cell'', 17 October 2007〕 Centralspindlin oligomerizes in order to link the mitotic spindle with the plasma membrane〔 The sequences mediating interactions between KIF23 and RacGAP1 are highly variable between species. However, a high affinity interaction between these subunits is essential for the proper functioning of the Centralspindlin complex.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Centralspindlin」の詳細全文を読む スポンサード リンク
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