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|Section2= |Section7= |Section8= }} Chloroacetaldehyde is the organic compound with the formula ClCH2CHO. Like some related compounds, it is highly electrophilic reagent and a potentially dangerous alkylating agent. The compound is not normally encountered in the anhydrous form, but rather as the hydrate (acetal), ClCH2CH(OH)2. Chloroacetaldehyde is a useful intermediate in the synthesis, e.g. of 2-aminothiazole or many pharmaceutical compounds. Another use is to facilitate bark removal from tree trunks. ==Synthesis and reactions== The hydrate of chloroacetaldehyde is produced by the chlorination of aqueous vinyl chloride: :ClCH=CH2 + Cl2 + H2O → ClCH2CHO + 2 HCl It can also be prepared from vinyl acetate.〔Reinhard Jira, Erwin Kopp, Blaine C. McKusick, Gerhard Röderer, Axel Bosch, Gerald Fleischmann "Chloroacetaldehydes" in Ullmann's Encyclopedia of Industrial Chemistry, 2007, Wiley-VCH, Weinheim. 〕 The related bromoacetaldehyde is prepared via bromination of vinyl acetate. It also rapidly forms a acetals in the presence of alcohols.〔S. M. McElvain and D. Kundiger "Bromoacetal" Organic Syntheses 1943, volume 23, p. 8. .〕 Being bifunctional, chloroacetaldehyde is a versatile precursor to many heterocyclic compounds. It condenses with thiourea derivatives to give aminothiazoles. This reaction was once important as a precursor to sulfathiazole, one of the first sulfa drugs.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Chloroacetaldehyde」の詳細全文を読む スポンサード リンク
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