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Chloroprednisone : ウィキペディア英語版 | Chloroprednisone
Chloroprednisone is a topical glucocorticoid first reported in 1960.〔Batres, Enrique; Bowers, Albert; Djerassi, Carl; Kincl, Fred A.; Mancera, Octavio; Ringold, Howard J.; Rosenkranz, Jorge; Zaffaroni, Alejandro. 6α-Chloro- or 6α-fluoro-1,4-pregnadiene-3,20-diones. (1960) 〕 It is a chlorinated derivative of prednisone. The acetate ester prodrug, chloroprednisone 21-acetate, was sold under the brand name Topilan as an anti-inflammatory agent.〔''Merck Index'', 11th Edition, 2157〕 There is little published about chloroprednisone. This may be due to limited activity topically because the skin lacks the necessary activating enzyme 11-Beta hydroxysteroid dehydrogenase. Systemically, this agent's activity on Glucocorticoid receptors may not have competed with agents like Fludrocortisone or Dexamethasone. ==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Chloroprednisone」の詳細全文を読む
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