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・ Chloroxylon
・ Chloroxymorphamine
・ Chlorozancla
・ Chlorozotocin
・ Chlorphenamine
・ Chlorphenesin
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・ Chlorproethazine
・ Chlorproguanil
・ Chlorproguanil hydrochloride-dapsone-artesunate
・ Chlorproguanil/dapsone
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Chlorprothixene
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・ Chlorurus microrhinos
・ Chlorurus perspicillatus


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Chlorprothixene : ウィキペディア英語版
Chlorprothixene

Chlorprothixene (Cloxan, Taractan, Truxal) is a typical antipsychotic drug of the thioxanthene class and was the first of the series to be synthesized. It was introduced in 1959 by Lundbeck.
Chlorprothixene is not approved for use in the United States.
== Pharmacology ==

Chlorprothixene exerts strong antagonism at the following receptors:
* 5-HT2: antipsychotic effects, anxiolysis, weight gain
* D1, D2, D3: antipsychotic effects, sedation, extrapyramidal side effects, prolactin increase, depression, apathy/anhedonia, weight gain
* H1: sedation, weight gain
* mACh: anticholinergic effects, inhibition of extrapyramidal side effects
* α1-adrenergic: hypotension, tachycardia
Chlorprothixene does also act as FIASMA (functional inhibitor of acid sphingomyelinase).
One metabolite of chlorprothixene is ''N''-demethylchlorprothixene.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Chlorprothixene」の詳細全文を読む



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