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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Ciclazindol ： ウィキペディア英語版 Ciclazindol Ciclazindol (WY-23,409) is an antidepressant and anorectic drug of the tetracyclic chemical class that was developed in the mid to late 1970s, but was never marketed. It acts as a norepinephrine reuptake inhibitor, and to a lesser extent as a dopamine reuptake inhibitor. Ciclazindol has no effects on the SERT, 5-HT receptors, mACh receptors, or α-adrenergic receptors, and has only weak affinity for the H1 receptor. As suggested by its local anesthetic properties, ciclazindol may also inhibit sodium channels. It is known to block potassium channels as well. ==Synthesis== Ciclazindol can be synthesized from isitin (1). Reaction with 2-chlorophenylmagnesium bromide thus gives 2. Conjugate addition of the anion of that product to acrylonitrile affords the propionitrile 3. The cyano group is then reduced to the primary amine by means of lithium aluminum hydride. Internal imine formation leads to cyclization to form ciclazindol. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Ciclazindol」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.