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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Cixutumumab ： ウィキペディア英語版 Cixutumumab Cixutumumab is a monoclonal antibody for the treatment of solid tumors.〔(Statement On A Nonproprietary Name Adopted By The Usan Council - Cixutumumab ) ''American Medical Association.''〕 This drug was developed by ImClone Systems Inc. under the name IMC-A12. It is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R) with potential antineoplastic activity. Cixutumumab selectively binds to membrane-bound IGF-1R, thereby preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signaling pathway. Downregulation of the PI3K/AKT survival pathway may result in the induction of cancer cell apoptosis and may decrease cancer cellular proliferation. IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by many cancer cell types, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been implicated in tumorigenesis and metastasis.〔() ''National Cancer Institute''〕 == References == 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Cixutumumab」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.