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Clofedanol
Clofedanol (INN) or chlophedianol (BAN) is a centrally acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses. It is marketed in Canada under the trade name Ulone, but is not available currently in the United States. In August 2009, Centrix Pharmaceutical announced the launch of a cough syrup containing a mixture of clophedianol and pseudoephedrine, marketed under the brand name ''Clofera''. It has a release to market date in the beginning of the fourth quarter 2009.〔(【引用サイトリンク】 Centrix Pharmaceutical Announces Clofera(TM), a Unique Antitussive and Nasal Decongestant for the Temporary Relief of Cough and Nasal Congestion )〕 Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process〔(【引用サイトリンク】 Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the0counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57 )〕 and its safety and efficacy data are limited.
==Synthesis==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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