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Colicin
A colicin is a type of bacteriocin produced by and toxic to some strains of ''Escherichia coli''.〔
* Feldgarden, M., & Riley, M. A. (August 1999). The phenotypic and fitness effects of colicin resistance in Escherichia coli K-12" ''Evolution'' 53(4), 1019-27. ()〕 Colicins are released into the environment to reduce competition from other bacterial strains. Colicins bind to outer membrane receptors, using them to translocate to the cytoplasm or cytoplasmic membrane, where they exert their cytotoxic effect, including depolarisation of the cytoplasmic membrane, DNase activity, RNase activity, or inhibition of murein synthesis.
==Structure==
Channel-forming colicins (colicins A, B, E1, Ia, Ib, and N) are transmembrane proteins that depolarize the cytoplasmic membrane, leading to dissipation of cellular energy. These colicins contain at least three domains: an N-terminal translocation domain responsible for movement across the outer membrane and periplasmic space; a central domain responsible for receptor recognition; and a C-terminal cytotoxic domain responsible for channel formation in the cytoplasmic membrane.〔Cascales et al. (2007). ''Colicin Biology''. Microbio. and Mol. Bio. Rev. 71(1), 158-229. (Abstract )(pdf )〕 One domain regulates the target and binds to the receptor on the sensitive cell. The second is involved with translocation, co-opting the machinery of the target cell. The third is the 'killing' domain and may produce a pore in the target cell membrane, or act as a nuclease to chop up the DNA or RNA of the target cell.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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