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Conatumumab
Conatumumab (originally AMG 655) is a monoclonal antibody developed for the treatment of cancer. it is a fully human monoclonal agonist antibody directed against the extracellular domain of human TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) receptor 2 (TR-2, death receptor 5) with potential antineoplastic activity. Conatumumab mimics the activity of native TRAIL, binding to and activating TR-2, thereby activating caspase cascades and inducing tumor cell apoptosis. TR-2 is expressed by a variety of solid tumors and cancers of hematopoietic origin.〔(Statement On A Nonproprietary Name Adopted By The USAN Council – Conatumumab ), ''American Medical Association''.〕〔(National Cancer Institute: Definition of conatumomab )〕 The drug was developed by Amgen Inc. ==Clinical trials== It will be included in the forthcoming I-SPY2 breast cancer trial.〔http://www.reuters.com/article/idUSN1612347120100317 "Breast cancer study aims to speed drugs, cooperation" March 2010〕
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