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Coronin Coronin is an actin binding protein which also interacts with microtubules and in some cell types is associated with phagocytosis. Coronin proteins are expressed in a large number of eukaryotic organisms from yeast to humans. ==Discovery==
Initially, a 55 kDa protein was isolated from the actomyosin complex of ''Dictyostelium discoideum'', which was later shown to bind actin in vitro. This actin binding protein was named coronin after its strong immunolocalisation in the actin rich crown like extension of the cell cortex in ''D. discoideum''. Initially this protein was admitted into club of actin binding proteins with least enthusiasm, as the primary structure did not match any other ABPs. But null mutation of coronin in ''D. discoideum'' resulted in impaired cytokinesis, and many actin mediated processes like endocytosis, cell motility etc. Later on, the protein was identified in many eukaryotic cells.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Coronin」の詳細全文を読む
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