|
Cospin is a serine protease inhibitor from the mushroom species ''Coprinopsis cinerea'' in the phylum Basidiomycota. == Cospin () == It has similar biochemical properties to other well characterized fungal serine protease inhibitors of family I66 in the MEROPS classification.〔Rawlings N. D. (2010) Peptidase inhibitors in the MEROPS database. Biochimie 92, 1463–1483 ()〕〔Kudryavtseva O., Dunaevsky Y., Kamzolkina O., Belozersky M. (2008) Fungal proteolytic enzymes: Features of the extracellular proteases of xylotrophic basidiomycetes. Microbiology 77, 643–653〕〔Nakamura M., Iketani A., Shioi Y. () A survey of proteases in edible mushrooms with synthetic peptides as substrates. Mycoscience 52, 234–241〕〔Odani S., Tominaga K., Kondou S., Hori H., Koide T., Hara S., Isemura M., Tsunasawa S. (1999) The inhibitory properties and primary structure of a novel serine proteinase inhibitor from the fruiting body of the basidiomycete, Lentinus edodes. Eur. J. Biochem. 262, 915–923 PubMed〕 Cospin is one of the few serine protease inhibitors of basidiomycete that have been isolated and characterized.〔Sabotic J., Trcek T., Popovic T., Brzin J. (2007) Basidiomycetes harbor a hidden treasure of proteolytic diversity. J. Biotechnol. 128, 297–307 PubMed〕 It is highly expressed in sexual reproductive structures termed fruiting bodies and has been cloned and characterized at the molecular and functional levels. == Genetic background == The cospin PIC 1 gene sequence isolated from fruiting bodies of the C. cinerea strain AmutBmut can be found under GenBank TM accession number ACX48485.〔Sabotič J, Bleuler-Martinez S, Renko M, et al. Structural Basis of Trypsin Inhibition and Entomotoxicity of Cospin, Serine Protease Inhibitor Involved in Defense of Coprinopsis cinerea Fruiting Bodies. The Journal of Biological Chemistry. 2012;287(6):3898-3907.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Cospin」の詳細全文を読む スポンサード リンク
|