|
Tetracosactide (INN) (brand names Synacthen, Cortrosyn), also known as tetracosactrin (BAN) and cosyntropin (USAN), and the acetate ester, tetracosactide acetate (JAN) (brand names Cortrosina, Cortrosyn, Nuvacthen, Synacthen), also known as tetracosactrin acetate (BANM), is a synthetic peptide and analogue of adrenocorticotrophic hormone (ACTH) which is used clinically as a diagnostic agent. It consists of the first 24 (of a total of 39) amino acids of ACTH and retains full function of the parent peptide.〔〔(Cortrosyn information )〕 Tetracosactide stimulates the release of corticosteroids such as cortisol from the adrenal glands, and is used for the ACTH stimulation test to assess adrenal gland function.〔 ==Uses== Tetracosactide is used for diagnostic purposes (e.g. in short synacthen test). It is suitable for treatment of adrenal insufficiency of central origin. Synacthen is also being used in treatment of different types of drug registant epilepsia, particularly by pediatric neurologists. In patients with low cortisol levels or symptoms of adrenocortical insufficiency, tetracosactide can be used to diagnose Addison's disease. A failure for serum cortisol levels to increase after administration of tetracosactide makes a diagnosis of primary adrenocortical insufficiency more likely. An increase in cortisol upon administration of tetracosactide rules out the condition. The test may also be used to assess the function of the adrenal glands after successful treatment for Cushing's syndrome. Tetracosactide is also used in the opposite situation, when there is aldosterone hypersecretion due to either a unilateral adrenal adenoma (which is treated by surgical removal) or bilateral adrenal hyperplasia (treated by oral spironolactone). A procedure called adrenal venous sampling may be used pre-operatively to localize the source of aldosterone hypersecretion from either adrenal gland. A peripheral intravenous infusion of tetracosactide before and during the procedure stimulates cortisol production and thereby verifies catheter position. As well as its legitimate medical applications, it has been widely reported that tetracosactide has also been used as an illegal performance-enhancing drug by professional cyclists. It is known to be used as a doping agent to increase the secretion of glucocorticoids by adrenal glands. Tetracosactide has been used in the treatment of infantile spasms. Types of drug resistant epilepsy that can be treated with Synacthen: * West syndrome * Dravet syndrome * Lennox-Gastaut syndrome * uncertain etiology epilepsy * Kinsbourne syndrom when it accompanies neuroblastoma 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Tetracosactide」の詳細全文を読む スポンサード リンク
|