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Cripto
Cripto is an EGF-CFC or epidermal growth factor-CFC, which is encoded by the Cryptic family 1 gene.〔 Cryptic family protein 1B is a protein that in humans is encoded by the ''CFC1B'' gene.〔〔 Cryptic family protein 1B acts as a receptor for the TGF beta signaling pathway. It has been associated with the translation of an extracellular protein for this pathway.〔 The extracellular protein which Cripto encodes plays a crucial role in the development of left and right division of symmetry. Mutations of it could cause congenital heart disease.〔
Crypto is a glycosylphosphatidylinositol-anchored co-receptor that binds nodal and the activin type I ActRIB (ALK)-4 receptor (ALK4).〔〔
== Structure ==
Cripto is composed of two adjacent cysteine-rich motifs: the EGF-like and the CFC of an N-terminal signal peptide and of a C-terminal hydrophobic region attached by a GPI anchor,〔 which makes it a potentially essential element in the signaling pathway directing vertebrate embryo development.〔 NMR data confirm that the CFC domain has a C1-C4, C2-C6, C3-C5 disulfide pattern and show that structures are rather flexible and globally extended, with three non-canonical anti-parallel strands.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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