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Cryptophycin : ウィキペディア英語版 | Cryptophycin
Cryptophycins are a family of macrolide molecules that are potent cytotoxins and have been studied for potential antiproliferative properties useful in developing chemotherapy. They are members of the depsipeptide family. ==History== Cryptophycins were originally discovered in 1990 in cyanobacteria of the genus ''Nostoc''. Cryptophycins were patented as antifungal agents with an unknown mechanism of action and subsequently identified as microtubule inhibitors. Closely related molecules were reported in the marine sponge ''Dysidea arenaria'', which were first given the name ''arenastatins''. However, since cyanobacteria are common symbionts of sponges, it has been suggested that bacteria may be the true origin in cases where sponge and bacterial metabolites closely resemble one another. Nevertheless, study of the structure-activity relationships between the two subgroups of molecules led to improved understanding of their cytotoxic effects.
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