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Cyclorphan
Cyclorphan is an opioid compound that is a δ-opioid receptor agonist, a κ-opioid receptor agonist, and a μ-opioid receptor antagonist. Chemically, it is a morphinan and is related to levorphanol.〔 It was first synthesized in 1964 by scientists at Research Corporation.〔 (US Patent 3,285,922 )〕〔Varghese V & Hudlicky T. A Short History of the Discovery and Development of Naltrexone and Other Morphine Derivatives. Chapter 6 in Natural Products in Medicinal Chemistry, Volume 60 of Methods and Principles in Medicinal Chemistry. Ed. Stephen Hanessian. John Wiley & Sons, 2013. ISBN 9783527676552〕 In clinical trials, it had relatively long duration, good absorption, and provided strong pain relief but caused symptoms of psychosis, so its development was not continued.〔 ==References==
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