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Cyproheptadine , sold under the brand name Periactin or Peritol, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. == Medical uses == * Cyproheptadine is used to treat allergic reactions (specifically hay fever).〔(MedlinePlus Drug Information: Cyproheptadine )〕 It is also used to treat vasomotor mucosal edema, including vasomotor rhinitis and edema of the throat. * It has shown effectiveness in the treatment of nightmares, including those related to post-traumatic stress disorder. * It has been used in the management of moderate to severe cases of serotonin syndrome, a complex of symptoms associated with the use of serotonergic drugs,〔 such as selective serotonin reuptake inhibitors and monoamine oxidase inhibitors), and in cases of high levels of serotonin in the blood resulting from a serotonin-producing carcinoid tumor. * It can also be used as a preventive measure against migraine in children and adolescents.〔(UVA Neurogram: Treatment of Pediatric Migraine )〕〔(Netdoctor: Periactin )〕〔(Migraines in Children and Adolescents )〕 In Australia this is the only indication for which cyproheptadine is subsidised by the PBS. * It can relieve SSRI-induced sexual dysfunction and drug-induced hyperhidrosis (excessive sweating). * It is also used in the treatment of cyclical vomiting syndrome *Use of the drug can stimulate the appetite and may lead to weight gain, which is helpful for underweight people.〔(Long-term trial of cyproheptadine as an appetite stimulant in cystic fibrosis | Wiley Online Library )〕 * According to a small study, cyproheptadine hydrochloride has been found to improve sleep, calmness, and mood and energy levels, and to improve both negative and (sometimes even) positive psychotic symptoms in a subgroup of chronic schizophrenics who did not respond (either completely or sufficiently) to other therapies. * Cyproheptadine may improve akathisia in patients on antipsychotic medications. * In clinical trials in which cyproheptadine was used as an adjunct to antipsychotic treatment for patients with schizophrenia, an improvement in negative symptoms was seen. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Cyproheptadine」の詳細全文を読む スポンサード リンク
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