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Chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 403686009 | ImageFile = DAMGO.png | ImageSize = 300 px | IUPACName = N-(2-hydroxyethyl)-3-phenylpropanamide " TITLE="(2R)-2- propanoyl]amino]propanoyl]amino]acetyl]-methylamino]- N-(2-hydroxyethyl)-3-phenylpropanamide "> OtherNames = Ala2-MePhe4-Glyol5-Enkephalin, DAGO, DAMGE with high μ-opioid receptor specificity. It was synthesized as a biologically stable analog of δ-opioid receptor-preferring endogenous opioids, leu- and met-()].〔Handa BK, Land AC, Lord JA, Morgan BA, Rance MJ, Smith CF. "Analogues of β-LPH61–64 possessing selective agonist activity at μ-opiate receptors." ''European Journal of Pharmacology''. 1981 Apr 9;70(4):531-40. PMID 6263640. doi|10.1016/0014-2999(81)90364-2}}〕 Its structure is H-Tyr-D-Ala-Gly-N-MePhe-Gly-OH. DAMGO has been used in experimental settings for the possibility of alleviating or reducing opiate tolerance for patients under the treatment of an opioid. Such treatment on rats, adding DAMGO to morphine administration, showed that after seven days morphine had as much of an effect at the same dosage as the first day when administered together with DAMGO to the rats. Whereas a separate control group of rats that were administered the same dosage of morphine over the course of the same week, but without DAMGO, displayed an increased tolerance and lessened analgesic efficacy toward the end of that week.〔http://www.unisci.com/stories/20021/0125025.htm ''Reducing Tolerance To Morphine Could Aid Pain Therapy.'' Endocytosis of the Mu Opioid Receptor Reduces Tolerance And a Cellular Hallmark of Opiate Withdrawal, A.K. Finn and J. Whistler, Neuron Vol. No. 32 () 829-839〕 ==See also== * Morphiceptin 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「DAMGO」の詳細全文を読む スポンサード リンク
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