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DCPG : ウィキペディア英語版
DCPG

DCPG ((S)-3,4-DCPG) is a drug used in scientific research, which acts as a potent and subtype-selective agonist for the metabotropic glutamate receptor mGluR8. It has anticonvulsant effects in animal studies,〔Moldrich RX, Chapman AG, De Sarro G, Meldrum BS. Glutamate metabotropic receptors as targets for drug therapy in epilepsy. ''European Journal of Pharmacology''. 2003 Aug 22;476(1-2):3-16. PMID 12969743〕〔Folbergrová J, Druga R, Haugvicová R, Mares P, Otáhal J. Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid. ''Neuropharmacology''. 2008 Mar;54(4):665-75. PMID 18191956〕 and has also been investigated as a possible treatment for hyperalgesia.〔Marabese I, de Novellis V, Palazzo E, Scafuro MA, Vita D, Rossi F, Maione S. Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. ''Neuropharmacology''. 2007 Feb;52(2):253-62. PMID 17113112〕
==References==



抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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