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DEFA4
Defensin, alpha 4 (DEFA4), also known as neutrophil defensin 4 or HNP4, is a human defensin peptide that is encoded by the ''DEFA4'' gene. HNP4 is expressed in the granules of the neutrophil where it defends the host against bacteria and viruses. ==Function== Defensins are a peptide family of cytotoxic microbicides involved in innate immunity. Members of the defensin family are distinguished by a conserved six-cysteine motif. Several human alpha defensin genes including HNP4 are clustered on chromosome 8. ''DEFA4'' differs from other defensin genes by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. HNP4 inhibits corticotropin-stimulated corticosterone production.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「DEFA4」の詳細全文を読む
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