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24-dehydrocholesterol reductase
24-dehydrocholesterol reductase is a protein that in humans is encoded by the ''DHCR24'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1718 )〕
==Model organisms==
Model organisms have been used in the study of DHCR24 function. A conditional knockout mouse line, called ''Dhcr24tm1a(EUCOMM)Wtsi'' was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.〔〔 〕 Twenty-six tests were carried out on mutant mice and two significant abnormalities were observed.〔 Few homozygous mutant embryos were identified during gestation, and none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice and no further abmornalities were observed.〔
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