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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク DKK1 ： ウィキペディア英語版 DKK1 Dickkopf-related protein 1 is a protein that in humans is encoded by the ''DKK1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22943 )〕 == Function == This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the Wnt signaling pathway. Dickkopf WNT signaling pathway inhibitor 1 (Dkk1) is a protein-coding gene that acts from the anterior visceral endoderm.〔Schneider, V.A., and Mercola, M. (1999). Spatially distinct head and heart inducers within the Xenopus organizer region. Curr Biol 9, 800-809.〕 The dickkopf protein encoded by DKK1 is an antagonistic inhibitor of the WNT signaling pathway that acts by isolating the LRP6 co-receptor so that it cannot aid in activating the WNT signaling pathway. This inhibition plays a key role in heart, head and forelimb development during anterior morphogenesis of the embryo.〔Schneider, V.A., and Mercola, M. (2001). Wnt antagonism initiates cardiogenesis in Xenopus laevis. Genes Dev 15, 304-315.〕〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「DKK1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.