翻訳と辞書 Words near each other ・ DNA virus ・ DNA-(apurinic or apyrimidinic site) lyase ・ DNA-3-methyladenine glycosylase ・ DNA-3-methyladenine glycosylase I ・ DNA-3-methyladenine glycosylase II ・ DNA-binding domain ・ DNA-Binding Metallo-intercalators ・ DNA-binding protein ・ DNA-binding protein from starved cells ・ DNA-deoxyinosine glycosylase ・ DNA-directed DNA polymerase ・ DNA-directed RNA interference ・ DNA-encoded chemical library ・ DNA-formamidopyrimidine glycosylase ・ DNA-Functionalized Quantum Dots ・ DNA-PKcs ・ DNA-SCARS ・ DNA/RNA non-specific endonuclease ・ DNA2.0 ・ DNA2L ・ DNAA ・ DnaA ・ DnaB ・ DnaB helicase ・ DnaC ・ DnaD ・ DnaE ・ DnaG ・ DnaH ・ DNAH11 Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク DNA-PKcs ： ウィキペディア英語版 DNA-PKcs DNA-dependent protein kinase, catalytic subunit, also known as DNA-PKcs, is an enzyme that in humans is encoded by the ''PRKDC'' gene. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. == Function == DNA-PKcs is the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase called DNA-PK. The second component is the autoimmune antigen Ku. On its own, DNA-PKcs is inactive and relies on Ku to direct it to DNA ends and trigger its kinase activity.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5591 )〕 DNA-PKcs is required for the non-homologous end joining (NHEJ) pathway of DNA repair, which rejoins double-strand breaks. It is also required for V(D)J recombination, a process that utilizes NHEJ to promote immune system diversity. DNA-PKcs knockout mice have severe combined immunodeficiency due to their V(D)J recombination defect. Many proteins have been identified as substrates for the kinase activity of DNA-PK. Autophosphorylation of DNA-PKcs appears to play a key role in NHEJ and is thought to induce a conformational change that allows end processing enzymes to access the ends of the double-strand break. DNA-PK also cooperates with ATR and ATM to phosphorylate proteins involved in the DNA damage checkpoint. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「DNA-PKcs」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.