翻訳と辞書
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・ DNA-(apurinic or apyrimidinic site) lyase
・ DNA-3-methyladenine glycosylase
・ DNA-3-methyladenine glycosylase I
・ DNA-3-methyladenine glycosylase II
・ DNA-binding domain
・ DNA-Binding Metallo-intercalators
・ DNA-binding protein
・ DNA-binding protein from starved cells
・ DNA-deoxyinosine glycosylase
・ DNA-directed DNA polymerase
・ DNA-directed RNA interference
・ DNA-encoded chemical library
・ DNA-formamidopyrimidine glycosylase
・ DNA-Functionalized Quantum Dots
・ DNA-PKcs
DNA-SCARS
・ DNA/RNA non-specific endonuclease
・ DNA2.0
・ DNA2L
・ DNAA
・ DnaA
・ DnaB
・ DnaB helicase
・ DnaC
・ DnaD
・ DnaE
・ DnaG
・ DnaH
・ DNAH11
・ DNAH5


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DNA-SCARS : ウィキペディア英語版
DNA-SCARS
DNA-SCARS (short for DNA segments with chromatin alterations reinforcing senescence) are nuclear substructures with persistent DNA damage and DNA damage response proteins found in senescent cells. DNA-SCARS are associated with PML nuclear bodies and the accumulation of activated ATM, ATR, CHK2 and p53 proteins. They lack most of the characteristics of transient, reversible DNA damage foci: single-stranded DNA, active DNA synthesis, and DNA repair proteins RPA and RAD51. Telomere dysfunction-induced foci (TIF) are generally associated with DNA-SCARS.〔
Together with senescence-associated heterochromatin foci (SAHF), DNA-SCARS are one of the most prevalent nuclear markers of cellular senescence.
== History ==
DNA-SCARS were discovered by Judith Campisi and colleagues, who first described them in 2011, although most of its characteristics were previously known.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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