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・ DPHP
・ DPHS
・ DPI
・ DPI-221
・ DPI-287
・ DPI-3290
・ DPIE
・ DPK
・ Dpkg
・ DPL
・ DPL Inc.
・ DPLL
・ DPLL algorithm
・ DPM
・ DPM1
DPM2
・ DPM3
・ DPMA
・ DPMI
・ DPMO
・ DPMS
・ DPMS Panther Arms
・ DPN
・ DPNH-coenzyme Q reductase
・ DPNH-ubiquinone reductase
・ DPNI
・ DpnII restriction endonuclease family
・ DPO
・ Dpon-chen
・ DPP


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DPM2 : ウィキペディア英語版
DPM2

Dolichol phosphate-mannose biosynthesis regulatory protein is a protein that in humans is encoded by the ''DPM2'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8818 )
== Function ==

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins, defective ''N''-linked glycosylation and deficient ''O''-mannosylation of α-dystroglycan. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C-terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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